Our team integrates concepts of physics and biology to develop a model system for a retinal neuronal network.
The high accessibility and tunability of our in vitro system will allow us to address fundamental questions at the interface between physics and biology:
- What are the mechanical cues that guide the self-organization of retina tissues?
- How are light-induced neuronal signals processed within these tissues?
- Can we use these systems as powerful in vitro disease models?
To illuminate the role of mechanics, we will use ferrofluid droplets as mechanical actuators, a technique which has been developed by us (Serwane et al., Nature Methods, 2017) and has been used to understand the role of mechanics in 3D developing tissues (Mongera et al., Nature 2018).
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