Soft Condensed Matter Group
print


Breadcrumb Navigation


Content

Research

  • Physics of Cell Migration

    baukasten_migration_square

    Collective cell migration is a key element in morphogenesis, cancer formation and wound healing. The multicellular dynamics of epithelial cell layers were studied in experiment and theory over the last years. Yet little is known about cell patches of finite size that should lead over from single cell behavior to collective motion. Here we study the migration and proliferation of small assemblies of epithelial cells more

  • Nanoparticles and Gene Delivery

    baukasten_nanoparticles_square

    In gene and siRNA based therapy, therapeutic benefits rely on the efficient transfer of foreign nucleic acids into cells. We investigate synthetic complexes capable of readily carrying nucleic acid across the cell membrane. The self-assembly, size and structure of lipid- and polycation-DNA complexes, known respectively as lipoplexes and polyplexes, are studied. We also endeavor to quantify and model transfection at the single cell level using GFP reporter and single cell time-lapse microscopy. more

  • Kinetics of Single Cell Response

    baukasten_timelapse_square

    We are interested in the kinetics of cellular responses, in particular in gene expression after transfection and event cascades in cytotoxicity. Using live cell imaging on single cell arrays (LISCA) time courses from individual cells are monitored and analyzed based on mathematical models. Cellular microarrays help to resolve cellular heterogeneity, a hallmark of complex biological systems dominated by intrinsic fluctuations. more

  • Macromolecular Dynamics and Adsorption to Surfaces

    baukasten_macromolecules_2_square

    Biopolymers have unique properties with respect to their self-assembly, conformational dynamics, transport and interactions with interfaces. Fluorescently labeled biopolymers and proteins can be studied by Quantitative Fluorescence Microscopy (QFM) and Fluorescence Correlations Spectroscopy (FCS). more

  • Supported Membranes

    baukasten_surface_square

    Supported membranes are versatile biomimetic interfaces. We study the structure and dynamics of supported membranes on various solid supports in collaboration with the group of Bert Nickel. The control of fluidity, spacing and lateral organisation is a current research challenge. more

  • Microfabrication

    baukasten_microfabrication_square