List of open master's theses
Applications for a master's thesis in the group of Prof. Rädler are welcome at any time.
To apply for a master's thesis in the group of Prof. Rädler send a short motivation letter, your CV and maybe an overview of grades to email@example.com
Master's Thesis in x-ray physics:
Small-angle X-ray scattering on photo-switchable lipid membranes
Membranes are essential to life as they are ubiquitous in living materials and carry out highly specialised functions. The determination of their structure and its control is of great interest in fundamental science. The recent synthesis of a light switchable lipid (Azo-PC) enabled a new approach to study and control the properties of membranes. Azo-PC undergoes a reversible photo-isomerisation of trans and cis state on UV or blue light exposure. This photo isomerisation induces a configurational change in the lipid, i.e. bending of one lipid chain, which further affects the overall structure of an Azo- PC membrane.
In the scope of this master thesis, you will use small-angle x-ray scattering to investigate Azo-PC membranes and their fundamental properties with our in-house setup as well as at a synchrotron light source like DESY. Together we want to extend the molecular control of Azo-PC to a functional control of photo switchable membranes in order to investigate the action of membrane-active peptides and transmembrane enzymes [1, 2, 3].
You will learn:
• Controlling of a complex x-ray scattering setup in-house and at DESY
• Design and fabrication of new setup components (soldering, milling, 3D printing)
• Biophysical laboratory skills
• Python programming for data analysis
• High motivation and strong academic record
• Interest in diffraction physics
• Basic programming skills
If you are interested, please contact Martina Ober (PhD Student) or Bert Nickel (PI) including short CV and transcript of records and we will show you our labs, group and the topic in more detail: firstname.lastname@example.org & email@example.com
Master's Thesis in the group of Dr. Paulitschke
On-chip interferometric antimicrobial susceptibility testing in ultra-low volume
Extensive use of antibiotics worldwide leads to an increase of multi resistant bacteria . It is estimated that by 2050 the annual deaths due to resistant bacteria will have surpassed those by cancer. To fight this trend new antibiotics as well as fast and specific treatment of infections  are needed. Commonly used diagnostic methods need several hours to analyze an antimicrobial susceptibility.
To this end our patented, highly sensitive laser detection method enables antimicrobial susceptibility testing (AST) in less than 1h  instead of days. In future, this technique should be developed for clinical applications. Remaining big questions are the further reduction of AST-time as well as the testing volume for bacteria quick testing. In the scope of this master thesis you will especially investigate the bacterial growth, susceptibility and time-response in self-employed ultra-low volume slides (< 100 nl). You will be part of a young and motivated group developing a new standard in health care.
- semi-conductor fabrication techniques in our in-house clean room for our nanostructures sensor device
- bacterial cell handling and cultivation
- high-throughput AST testing
- design and fabrication of a new and innovative microfluidic ultra-low volume slide
Also see Bacteriasensor.pdf
Master’s Thesis in Physics, Chemistry and Genetics Transforming Science into Diagnostics
At DEOXY, we develop an instrument that measures genomic activity.
We strive to develop a breakthrough technology that actually matters.
WHO WE ARE
DEOXY is a spinoff project based at the Ludwig-Maximilians-University (LMU) in Munich at the chair of Prof. Dr. Joachim Rädler. We are a closely collaborating team with backgrounds from research to industry and from physics to biology.
We are working on a technology for advanced genetic measurements. Based on which we will develop a product for scientists in biological research and for medical personnel in clinical diagnostics. Our integrated approach comprises of an automated instrument, nanoparticles (the magic), high-performance substrates and a data evaluation software suite.
We cherish and cultivate our team culture: the people we work with are important to us.
POSSIBLE TOPICS ARE
- DNA Origami
- Reaction kinetic analysis
- Algorithms for image analysis
- Bioinformatic algorithms for genetic analysis
- Fluorescence microscopy
- Genetic analysis of biological samples
- Substrate chemistry
- Fluidics and automation
Want to join the ride? Get in touch: firstname.lastname@example.org